Academics invade Dubrovnik

Dubrovnik Republicanism and its Ideologues

The Dubrovnik Republic existed as an autonomous political community, in complex geopolitical conditions, for no less than 450 years (1358-1808). Throughout this period the political system was neither changed nor was it seriously endangered from within. This makes the Dubrovnik Republic a unique phenomenon. The text puts forward a concise analysis of the historical-political circumstances, of t...

Partner up to invade

Partner up to invade A secretory complex and a cytoskeletal polarity protein cooperate to make tumor cells more invasive, according to new work from Sakurai-Yageta et al. To burrow into nearby tissue, tumor cells create membrane protrusions called invadopodia. Within invadopodia, vesicles accumulate that contain metalloproteinase enzymes needed to degrade the extracellular matrix. Because a sec...

The Old Port of Dubrovnik

Can adaptive dynamics invade?

Working Papers are interim reports on work of the International Institute for Applied Systems Analysis and have received only limited review. Views or opinions expressed herein do not necessarily represent those of the Institute, its National Member Organizations, or other organizations supporting the work. ADN The Adaptive Dynamics Network at IIASA fosters the development of new mathematical a...

A way to invade

Overexpression of the ErbB2 (Her2/neu) receptor tyrosine kinase is implicated in the induction and progression of many different types of human cancers. It is particularly frequent in breast cancer, where up to 25% of patients overexpress ErbB2. The ErbB2-positive cancers exhibit extremely malignant and invasive behavior, which is associated with increased disease recurrence and worsened progno...